Business / Agriculture / Maximum Tolerated Dose (MTD): Loosely, the highest dose of a chemical that when administered to a group of test animals does not increase the death rate during a long-term study. The purpose of administering MTD is to determine whether long-term exposure to a chemical might lead to any adverse health effects in a population, when the level of exposure is not sufficient to cause premature mortality due to short-term toxic effects. The maximum dose is used, rather than a lower dose, to reduce the number of animals that need to be tested (and thus, the cost of animal testing), in order to detect an effect that occurs only rarely. This analysis is used in establishing chemical residue tolerances in foods.
Search Google for Maximum Tolerated Dose (MTD):
Dose Adjective Synonyms: portion, quantity, amount, measure, dosage
Dose Noun Synonyms: dispense, administer, prescribe
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Maximum Noun Synonyms: most, utmost, uttermost, greatest, peak, extreme, extremity, pinnacle, top, highest, (upper) limit
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Science / Biology / Maximum Sustainable Yield (MSy): The maximum number of a food or game population that can be harvested without harming the populations ability to grow back. MORE
Technology / Aviation / Maximum Takeoff Weight: The maximum weight of any aircraft on takeoff without exceeding its load factor. (MTOW) MORE
Business / Agriculture / Maximum Tolerated Dose (MTD): Loosely, the highest dose of a chemical that when administered to a group of test animals does not increase the death rate during a long-term study. The purpose of administering MTD is to determine wh MORE